Different behavior parameters were used to test the anti-hyperalgesic and anti-allodynic effect of PSO, NCF, and LC on days 0, 7, 14, 21, and 28 of PT administration. PSO, NCF, and LC were administered orally once daily to mice with PT-induced neuropathy in their corresponding groups. p., once weekly) to the mice in all groups except C group. NP was induced by the administration of PT (6 mg/kg, i.
Materials and Methods: Thirty adult male mice were divided equally into five groups of six mice in each group as follows: Control (C), PT, PSO (PTpso), NCF (PTn), and LC (PTc) groups. The aim of this study is to compare the anti-hyperalgesia and anti-allodynia activity of PSO, NCF, and LC in PT-induced neuropathy.
Nucleo-CMP Forte® (NCF) is a nucleotide-based drug and L-carnitine (LC) is a member of natural compounds have been shown effective in diverse peripheral neuroglial disorders. Pomegranate seed oil (PSO) has been used in the traditional medicine for the different kinds of pain. The less significant anti-nociceptive effect of LC than PSO and NCF shown in the present study could be related to that it has protective effect on C-fiber mitochondria rather than the A-fiber mitochondria which is evoked in PT neuropathy.īackground: Hyperalgesia and allodynia are abnormal sensory signs which are usually seen along neuropathic pain (NP) in patients on paclitaxel (PT) chemotherapy. The analgesic effect of LC had gained much interest in different forms of neuropathy conditions, and the significant anti-nociceptive effect of LC shown in the present study is in agreement with the findings of other clinical studies and experimental models of NP including chemotherapy-induced NP that confirmed the important role of LC in maintaining mitochondrial energy homeostasis and detoxification, nerve growth factor, and promoting peripheral nerve regeneration.
The significant improvements in withdrawal latency obtained with NCF administration in PIPN compared to PTc group shown in this study indicate it possess neuroprotective and anti-nociceptive activity, which have also been demonstrated in different types of neurological conditions that elucidate its role in the structural neuroregeneration since nucleotides serve as a potential source of extracellular ATP and other purines that regulate the actions of many processes in the body including neurons. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly.